Gabbiani Lab
Principal Investigator: Fabrizio Gabbiani
Institution: Baylor College of Medicine (Houston, TX)
Primary Subfield: Neuroscience
Recruitment Status: ✅ Hiring Postdocs
Research Focus
The long-term objective of this proposal is to integrate the design of experiments and computational large-scale parameter estimation to advance the understanding of a central problem in neuroscience: How and whether the subcellular localization of ion channels in dendritic compartments contributes to single neuron computation. This problem can only be addressed using neurons whose biophysical properties are well characterized and whose role in the processing of sensory information and the generation of behavior is well understood. The focus will be on three channel types that play a key role in synaptic integration: hyperpolarization-activated, cyclic nucleotide-gated, mixed sodium/potassium channels, transient dendritic potassium channels, and calcium channels involved in the generation of burst firing. The specific aims will focus (i) on determining how these channels, in particular calcium channels, contribute to the dendritic excitability of hippocampal pyramidal cells; and (ii) on determining how the same channels contribute to visual object segmentation in collision detecting neurons. Additionally, the project will (iii) develop a broader, integrated large-scale modeling opt…
Active NIH Awards
- 5R01NS130917-05: CRCNS: Understanding Single-Neuron Computation Using Nonlinear Model Optimization (2026)
- 5R01NS130917-04: CRCNS: Understanding Single-Neuron Computation Using Nonlinear Model Optimization (2025)
- 5R01NS130917-03: CRCNS: Understanding Single-Neuron Computation Using Nonlinear Model Optimization (2024)
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