Lonard Lab
Principal Investigator: David M Lonard
Institution: Baylor College of Medicine (Houston, TX)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Hiring Postdocs
Research Focus
PROJECT SUMMARY Advancing our mechanistic understanding of androgen-dependent male reproductive function requires an in- depth structural understanding of the core transcriptional complex in which ligand-occupied androgen receptor (AR) in complex with steroid receptor coactivator-2 (SRC-2) and p300 enacts transcriptional initiation of specific androgen-responsive gene expression programs. Until recently, structural information on the assembly modes by which the nuclear receptor (NR) engages with primary and secondary coregulators (Coregs) was limited to studies based on NR and Coreg protein fragments, which provided a significantly incomplete and, in many cases, an erroneous perspective of NR/Coreg transcriptional complex formation. To address this limitation, my team recently used cryogenic electron microscopy (cryo-EM) and proteomics to solve the quaternary structure of a number of NR/Coreg transcriptional complexes related to cancer biology at a full-length structural level. Apart from providing essential insights into the structure and assembly mechanisms of these core transcriptional complexes, an important “take away” from these investigations was that the structure and stoic…
Active NIH Awards
- 5R01HD008188-53: Reproductive Hormones - Biological and Molecular Actions (2026)
- 5R01HD007857-54: Sex Hormone Receptor Component And The Cell Genome (2026)
- 5R01HD007857-53: Sex Hormone Receptor Component And The Cell Genome (2025)
- 2R01HD008188-52A1: Reproductive Hormones - Biological and Molecular Actions (2025)
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