Sheth Lab
Principal Investigator: Sameer Anil Sheth
Institution: Baylor College of Medicine (Houston, TX)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Project Summary Depression is one of the most common disorders of mental health, affecting 7–8% of the population and causing tremendous disability to afflicted individuals and economic burden to society. In order to optimize existing treat- ments and develop improved ones, we need a deeper understanding of the mechanistic basis of this complex disorder. Previous work in this area has made important progress but has two main limitations. (1) Most studies have used non-invasive and therefore imprecise measures of brain activity. (2) Black box modeling used to link neural activity to behavior remain difficult to interpret, and although sometimes successful in describing activity within certain contexts, may not generalize to new situations, provide mechanistic insight, or efficiently guide therapeutic interventions. To overcome these challenges, we combine precise intracranial neural recordings in humans with a suite of new eXplainable Artificial Intelligence (XAI) approaches. We have assembled a team of exper- imentalists and computational experts with combined experience sufficient for this task. Our unique dataset comprises two groups of subjects: the Epilepsy Cohort consists of patien…
Active NIH Awards
- 5R01MH130597-04: Intracranial Investigation of Neural Circuity Underlying Human Mood (2026)
- 5U01NS121472-05: Mapping Algorithmic State Space in the Human Brain (2025)
- 5R01MH130597-03: Intracranial Investigation of Neural Circuity Underlying Human Mood (2025)
- 5UH3NS103549-06: Deep Brain Stimulation for Depression Using Directional Current Steering and Individualized Network Targeting (2025)
- 5U01NS121472-04: Mapping Algorithmic State Space in the Human Brain (2024)
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