Nayor Lab
Principal Investigator: Matthew G. Nayor
Institution: Boston Medical Center (Boston, MA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY/ABSTRACT Heart failure (HF) with preserved ejection fraction (HFpEF) represents ≈50% of HF, with limited methods for prevention and treatment. Current approaches to detect/treat HFpEF rely on cardiac phenotypes obtained at rest, missing reserve capacity impairments in multiple organ systems central to HFpEF that are uniquely revealed through exercise. In the first R01 period, we performed 3117 cardiopulmonary exercise tests (CPETs) in the Framingham Heart Study (FHS) to quantify cardiorespiratory fitness, individual exercise responses, and their metabolomic signatures. We defined a “normal” metabolic response to exercise and reported novel measures of impaired fitness and HF risk. Strikingly, ≈1 in 4 asymptomatic community-dwelling FHS participants displayed fitness impairment that overlapped with individuals with hemodynamically confirmed HFpEF studied in our clinical referral lab. Metabolites related to HFpEF physiology were also associated with exercise responses in FHS. These results underscore a critical molecular and phenotypic overlap between clinical HFpEF and the early stages of its development, providing a unique opportunity to define the origins of HFpEF…
Active NIH Awards
- 5R01HL131029-08: Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF Spectrum (2026)
- 5R01HL156975-05: Metabolic Responses to an Oral Mixed Meal Tolerance Test: Intra-individual changes, correlates, and prognostic significance (2025)
- 5R01HL131029-07: Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF Spectrum (2025)
- 5R01HL131029-06: Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF Spectrum (2024)
- 5R01HL156975-04: Metabolic Responses to an Oral Mixed Meal Tolerance Test: Intra-individual changes, correlates, and prognostic significance (2024)
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