Chen Lab
Principal Investigator: Fei Chen
Institution: Broad Institute (Cambridge, MA)
Primary Subfield: Genetics/Genomics
Recruitment Status: ✅ Hiring Postdocs
Research Focus
The contemporary clinical successes of immunotherapies have highlighted the key role of tumor-infiltrating cells in mediating anti-tumor immunity and have generally associated the presence of T cells within tumors with therapeutic response. However, until now, a systematic approach for evaluating how T cell state, their clonal identity and localization are related has not been possible. In recent years, the Wu lab has achieved several notable technical advances, including generation of a best-in-class HLA class I epitope predictor (HLAthena); a highly robust targeted plate-based method for single-cell TCR sequencing (rhTCRseq); and a means to parallelize the cloning of hundreds of TCRs such that they can be interrogated to definitively link a TCR with its antigen specificity. Because dynamic interactions between tumor-reactive T cells and malignant clones occur within the defined spatial ordering of tissue, our valuable new insights motivate us to investigate how the spatial organization of tumor-specific T cells relates to in situ positioning of tumor clones. We hypothesize that antigen specificity, which drives the interactions between T cells and tumor cells, impacts the distinc…
Active NIH Awards
- 5R01CA276865-04: Spatial genomic tools to interrogate T cell clonotypes, tumor clones and the microenvironment (2026)
- 5R01HG013336-02: Multiplexed Locus-Specific Hypermutation for Functional Characterization of the Coding and Noncoding Genome (2026)
- 5R01HG010647-07: A platform for scalable spatial single cell genomics (2026)
- 5R33CA291199-03: A platform for multi-modal single nucleus spatial genomics for molecular tumor analysis (2026)
- 5UH3NS132135-04: A Platform for Scalable Spatial Somatic Variant Profiling (2026)
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