Fishell Lab
Principal Investigator: Gordon J Fishell
Institution: Broad Institute (Cambridge, MA)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Grant Summary Neuromodulatory systems—comprising noradrenergic, serotonergic, cholinergic, and dopaminergic neurons—play a critical role in regulating mood, cognition, motor control, and physiological processes. These systems are central to understanding how the brain encodes reward, action selection, and memory, and they remain key therapeutic targets for neuropsychiatric and neurodegenerative disorders. Recent advances in high-throughput single-cell and spatial genomics have revealed a remarkable diversity among neuromodulatory cell types, with dozens to hundreds of distinct subpopulations. Despite this, tools capable of targeting these subpopulations with precision remain limited, hindering progress in both basic and translational neuroscience. This project seeks to address this gap by developing a comprehensive pipeline to nominate, validate, and disseminate cell-type-specific enhancers for neuromodulatory systems. Building upon prior successes in enhancer discovery for cortical interneurons and pyramidal neurons, we will employ advanced spatial multiomic profiling, computational prediction, and high-throughput AAV-based enhancer testing to generate a robust set of validated en…
Active NIH Awards
- 1U01MH142288-01: Using Enhancer-directed expression within AAVs to target subtypes within the four major neuromodulatory populations (2026)
- 5R01NS081297-13: The Development and Integration of Early Born SST-Expressing Interneurons in the Cortex (2026)
- 5R37MH071679-21: The molecular and cellular basis of cortical interneuron divergence (2026)
- 5R37MH071679-20: The molecular and cellular basis of cortical interneuron divergence (2025)
- 5R01NS081297-12: The Development and Integration of Early Born SST-Expressing Interneurons in the Cortex (2025)
Explore 700+ US Biology Labs on FindBioLabs.com