Abdelfattah Lab
Principal Investigator: Ahmed Abdelfattah
Institution: Brown University (Providence, RI)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY Neural cell types play distinct roles in brain computation, and cell-type-specific activity patterns are crucial for learning. Cell-type-specific recordings of rapid electrical signals are critical for fully understanding neural computation and the vulnerabilities of different cell types in disease contexts. However, current technologies for measuring membrane potential have limitations: while whole-cell recording is the gold standard, it is not high-throughput. Our team previously developed the genetically encoded voltage sensor, Voltron, which offers high sensitivity and fast speed. Despite these advancements, the existing membrane voltage sensor toolkit imposes severe constraints on the number of different cell types that can be imaged in vivo and does not allow for quantification of absolute membrane voltage, rather reports only relative membrane voltage changes, and has restricted depth penetration. This project aims to address these challenges by developing and validating a palette of novel chemigenetic sensors for in vivo quantitative multiplexed FLIM voltage imaging. Close collaboration among the Abdelfattah, Yasuda, and Inagaki labs will leverage their comp…
Active NIH Awards
- 1R01MH141441-01A1: Development of genetically encoded sensors and high-speed FLIM for in vivo quantitative multiplexed voltage imaging (2026)
- 4DP2MH129956-02: Lighting up the brain: Optogenetic tools to record, trace, and manipulate brain circuits at cellular resolution (2024)
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