Robb Lab
Principal Investigator: Maxwell J Robb
Institution: California Institute of Technology (Pasadena, CA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Hiring Postdocs
Research Focus
Project Summary / Abstract Research in the Robb group is focused on expanding the frontiers of the emergent field of polymer mechanochemistry, where mechanical force is harnessed to selectively activate productive chemical transformations in stress-sensitive molecules known as mechanophores. Our expertise is in the molecular design and development of new mechanophores and reaction strategies, enabling access to stimuli-responsive polymers that address challenges in a variety of areas including stress sensing and mechanically triggered molecular release. Our research advances the fundamental understanding of mechanochemical reactivity through the development of structure–activity relationships and novel molecular design principles, providing a foundation for creating innovative materials. Nevertheless, critical gaps remain that have limited the translation of polymer mechanochemistry to applications in biology and medicine. In this proposal, we outline a multifaceted approach for the development of systems that enable acoustically controlled molecular delivery from mechanochemically active polymers using biocompatible focused ultrasound, specifically targeting biological application…
Active NIH Awards
- 5R35GM150988-04: Development of Chemical Platforms for Acoustically Controlled Molecular Delivery (2026)
- 5R35GM150988-03: Development of Chemical Platforms for Acoustically Controlled Molecular Delivery (2025)
- 5R35GM150988-02: Development of Chemical Platforms for Acoustically Controlled Molecular Delivery (2024)
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