Haines Lab
Principal Investigator: Jonathan L Haines
Institution: Case Western Reserve University (Cleveland, OH)
Primary Subfield: Genetics/Genomics
Recruitment Status: ✅ Hiring Postdocs
Research Focus
Alzheimer disease (AD) is the fifth most frequent cause of death in the U.S. and currently affects nearly 55 million individuals of all ancestries worldwide; this number is predicted to double over the next 20 years. Clinical trials for effective therapeutics have almost all failed, and the few currently approved treatments provide only modest slowing of progression for a subset of individuals, with potentially severe side effects. Thus, focusing on additional and alternative therapeutic targets is critical to address this increasing health crisis. Genetically driven targets significantly improve the probability of successful clinical trials, but despite the identification of numerous AD-associated loci through GWAS, few have advanced to potential therapeutic intervention. In part, this is because GWAS itself is a blunt instrument that cannot differentiate among the many genes often underlying an associated locus. This leaves a critical gap where numerous GWAS-identified loci have not been sufficiently examined to support or refute their candidacy as a therapeutic target. ADAPTT aims to fill this knowledge gap by leveraging all available data from the growing datasets of the Alzhei…
Active NIH Awards
- 1R01AG096172-01: Alzheimer Disease Genetic Analysis to Identify Potential Therapeutic Targets (ADAPTT) (2026)
- 5R01AG058066-06: Protective Genetic Variants for Alzheimer Disease in the Amish - RENEWAL (2026)
- 2P30AG072959-06: Data Management & Statistical Core - Cleveland ADRC (2026)
- 5R01AG058066-05: Protective Genetic Variants for Alzheimer Disease in the Amish - RENEWAL (2025)
- 5P30AG072959-05: Data Management and Statistics Core (2025)
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