Hubert Lab
Principal Investigator: Christopher G Hubert
Institution: Case Western Reserve University (Cleveland, OH)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY / ABSTRACT: Glioblastoma (GBM) is a uniformly fatal brain cancer driven by a small population of self-renewing, highly tumorigenic cells termed GBM stem cells (GSCs). Our long-term goal is to find improved therapeutics for GBM by better understanding the biology that drives this disease. GBM tumors have a complex microenvironment including a relatively proliferative perivascular niche containing GSCs enriched for the stem cell marker SOX2+, and a distinct hypoxic niche that regulates resident GSCs through hypoxic signaling factors. Because the cells within distinct GBM tumor regions are remarkably different from each other, we believe that individual tumor microenvironments must be targeted with unique niche-specific therapies. However, current culture models fail to replicate the complex microenvironments of GSCs, limiting our ability to study and therapeutically target GBM. We therefore developed patient-derived GBM organoids, a controlled ex-vivo system that contains both proliferative and hypoxic niches, as well as gradients of stem and non-stem cells similar to those observed in patient tumors. We developed methods to 3-dimensionally label the separate niches o…
Active NIH Awards
- 5R01NS126253-04: Therapeutic Targeting of WDR5 in the Glioblastoma Perivascular Niche (2026)
- 2P01CA245705-07: Project 2 Sex-skewed transcription factor function drives self-renewal and vascular dynamics (2026)
- 5R01NS126253-03: Therapeutic Targeting of WDR5 in the Glioblastoma Perivascular Niche (2025)
- 5R01NS126253-02: Therapeutic Targeting of WDR5 in the Glioblastoma Perivascular Niche (2024)
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