Jin Lab
Principal Investigator: Fulai Jin
Institution: Case Western Reserve University (Cleveland, OH)
Primary Subfield: Genetics/Genomics
Recruitment Status: ✅ Hiring Postdocs
Research Focus
Project Abstract The organization of 3D architecture of mammalian genome is one of the major mysteries in biology. The invention of genome-wide chromosome conformation capture (3C) technologies, or Hi-C, have revealed a hierarchical 3D genome organization, including compartments corresponding to euchromatin and heterochromatin; with higher sequencing depth, Hi-C data further divided the genome into largely invariant topologically associated domains (TADs), which often serve as the boundary for long-range transcriptional regulation. Recently, with ultra-deep sequencing and improved analysis strategies at kilobase-scale resolution, Hi-C can identify chromatin loops within TADs connecting promoters and cis- regulatory elements in an unbiased fashion. Despite these progresses, an unexplored realm is the relationship between DNA sequence and 3D genome features, especially chromatin loops. It is important to elucidate how the transcription machinery translates the genetic variants into variable events at 3D genome levels and leads to transcriptional or physiological alterations. Here we propose to take an initial step solving the genetics of mammalian 3D genome using a panel of F1-hybrid…
Active NIH Awards
- 5R01HG012384-04: Mapping heritable chromatin loop variants with allele-specific Hi-C analysis (2026)
- 5R01HG009658-10: Robust mapping of chromatin loops from sparse or single cell Hi-C data with DeepLoop (2026)
- 5R01HG009658-09: Robust mapping of chromatin loops from sparse or single cell Hi-C data with DeepLoop (2025)
- 5R01HG012384-03: Mapping heritable chromatin loop variants with allele-specific Hi-C analysis (2025)
- 5R01HG012384-02: Mapping heritable chromatin loop variants with allele-specific Hi-C analysis (2024)
Explore 700+ US Biology Labs on FindBioLabs.com