Remy Lab
Principal Investigator: Kenneth Eugene Remy
Institution: Case Western Reserve University (Cleveland, OH)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT ABSTRACT This NIGMS MIRA will support an Early Stage Investigator and help bridge the widening gap between cutting-edge research and improving patient care in the field of hematology-immunology-infectious diseases, through the investigation of heme dysregulation of the innate and adaptive immune system in patients with sepsis or chronic hemolytic diseases ± red blood cell (RBC) transfusion as a function of circulating heme availability. Sepsis is an invasive infectious disease associated with dysregulated systemic inflammation and more than 4 million deaths worldwide per annum. Specific targeted therapies are lacking. Likewise, in chronic hemolytic diseases such as Sickle Cell Disease (SCD) and Thalassemia, > 50,000 patients have died over the past twenty years. Many patients (~50% in sepsis and >80% in chronic hemolytic diseases) receive a RBC transfusion as supportive therapy or have ongoing ‘low levels’ of intravascular hemolysis. Recent evidence from our laboratory indicate that this hemolysis may further disrupt a patient’s immune system and lead to worse outcomes. This disruption may be causally linked to release of free heme from the underlying hemolysis. We have rec…
Active NIH Awards
- 5R35GM160336-02: Heme-Based Immune Dysregulation in Critical Illness (2026)
- 1R21AI191916-01A1: Investigating Plasma Cell-Free Hemoglobin as a Driver of Cardiovascular Disease Risk in HIV-Positive Individuals (2026)
- 5R01HD115952-02: Refining Immune Heterogeneity in Pediatric Sepsis Multiple Organ Dysfunction Syndrome (2026)
- 1R21HL187010-01: Plasma Cell-Free Hemoglobin: A Potential Modulator of Immune Dysregulation in HIV (2026)
- 1R35GM160336-01: Heme-Based Immune Dysregulation in Critical Illness (2025)
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