Ngo Lab
Principal Investigator: John Tuan Ngo
Institution: Boston University (Boston, MA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Hiring Postdocs
Research Focus
PROJECT SUMMARY Notch receptors are mechanically activated transmembrane proteins that regulate cell fate, differentiation, proliferation, adhesion, and many other critical processes. Most studies to date have focused on understanding Notch from biochemical and genetic perspectives and have only recently been explored as a mechanoreceptor. Given Notch's varied roles in both standard and pathological states, it is necessary to formulate an integrated mechano-chemical perspective of Notch signaling and regulation, as such an outlook for a comprehensive understanding of this critical and evolutionarily conserved signaling pathway. In this project, my lab will leverage our expertise in chemical probe development and molecular tool design to address sharply focused mechanistic questions regarding Notch mechanotransduction. To distinguish our contributions from those of others, we will pursue a multi-scale understanding of the pathway by combining single molecule studies and high-resolution imaging to understand how the activation of the receptor is coupled to biomechanical events that occur within the cell. In particular, new correlative light and electron microscopy will be developed a…
Active NIH Awards
- 5R35GM128859-07: Integrative Approaches for Probing Cell Mechanotransduction in Health and Disease (2026)
- 2R35GM128859-06: Integrative Approaches for Probing Cell Mechanotransduction in Health and Disease (2025)
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