Reinhart Lab
Principal Investigator: Robert Reinhart
Institution: Boston University (Boston, MA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY/ABSTRACT In the past century, age-related deficits and dementia have surged, and this trend is expected to intensify with the rapidly aging global population. The decline in visual perception associated with aging significantly impacts health, well-being, and overall quality of life. Key aspects of the visual system, namely contrast sensitivity (the ability to distinguish objects from their backgrounds) and 3D structure-from-motion perception (the capacity to recover depth structure from object motion), undergo pronounced deterioration with age and in age-related diseases, such as Alzheimer's disease (AD). These functions are fundamental to human vision, highly informative of everyday perception, substantially compromised in aging and AD, and predictive of AD-related biomarkers, pathophysiology, and disease severity. Despite advancements in understanding age-related perceptual deficits, neurocomputational insights are lacking, and there are currently no available treatments for impaired perception in older age. Neuroscience theory suggests that the interaction between alpha (8-12 Hz) and gamma (>30 Hz) neural oscillations may indicate a cortical signaling state for…
Active NIH Awards
- 5R01AG082645-04: Personalized Synchronization of Cortical Rhythms to Improve Memory in Alzheimer's Disease (2026)
- 5R01AG090379-02: Rescuing Visual Perception in Aging Adults by Restructuring the Alpha-Gamma Neural Code (2026)
- 1R01AG097619-01: Personalized Memory Enhancement in Aging: Pattern-Optimized tACS with Closed-Loop Precision Modulation (2026)
- 1R01AG090379-01A1: Rescuing Visual Perception in Aging Adults by Restructuring the Alpha-Gamma Neural Code (2025)
- 5R01AG082645-03: Personalized Synchronization of Cortical Rhythms to Improve Memory in Alzheimer's Disease (2025)
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