Fromme Lab
Principal Investigator: J Christopher Fromme
Institution: Cornell University (Ithaca, NY)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Project Summary / Abstract A hallmark of eukaryotic cells is their compartmentalization. The evolution of membrane-bound organelles enabled separation, concentration, and specialization of functions critical for cell behavior. Yet this compartmentalization created challenges for cells, which must control the flow of material into and out of these organelles. Our lab's long-term goals are to elucidate how cells exert control over the flow of proteins and lipids within the endomembrane system. We seek to understand the Golgi complex, which serves as the nexus of many different trafficking pathways in eukaryotic cells. We have focused many of our investigations on the Golgi- localized GTPases, their regulators, and their effectors to determine how they govern protein trafficking through this enigmatic organelle. Research projects in our lab use multiple approaches, including protein biochemistry, live-cell imaging, in vitro reconstitution, and structural biology to discover fundamental mechanisms. Our work has resulted in significant advances in our understanding of how the function of the Golgi is regulated: we uncovered an extensive network of cross-talk interactions between GTPase…
Active NIH Awards
- 5R35GM136258-07: GTPase Regulation of the Golgi Complex (2026)
- 2R35GM136258-06: GTPase Regulation of the Golgi Complex (2025)
- 5R35GM136258-05: GTPase Regulation of the Golgi Complex (2024)
- 3R35GM136258-05S1: GTPase Regulation of the Golgi Complex (2024)
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