Rudd Lab
Principal Investigator: Brian David Rudd
Institution: Cornell University (Ithaca, NY)
Primary Subfield: Immunology
Recruitment Status: ✅ Hiring Postdocs
Research Focus
PROJECT SUMMARY / ABSTRACT T lymphocytes are adaptive immune cells that protect the host against a diverse array of pathogens. In the last decade, immunologists have started to learn how to harness the function of T cells for immune benefit, which has revolutionized the field of immunology and changed the way we treat a variety of immune-mediated diseases, including cancer. However, recent discoveries in the fields of immunology and hematopoiesis suggest that our current model of T cell development is out-of-date, which may be contributing to inefficient treatment approaches to immune-mediated diseases. Up until now, the dogma in the field has been that all T cells are generated from bone marrow-derived hematopoietic stem cells (HSCs), and that the T cell compartment is comprised of a single lineage of T cells that are created equally. However, stem cell biologists have recently discovered that there are a wide variety of non-HSC progenitors at different anatomical sites in early life that can produce T cells. In separate studies, immunologists have learned that T cells made in early life persist into adulthood and exhibit unique roles during infection and disease. The stem cell bi…
Active NIH Awards
- 5R21AI193994-02: Embryonic origins of T cells (2026)
- 5R37AI189855-02: Mapping infant and adult T cell immunity (2026)
- 2P01AI102851-11A1: Spatiotemporal regulation of T cell priming (2026)
- 1R21AI193994-01: Embryonic origins of T cells (2025)
- 1R37AI189855-01: Mapping infant and adult T cell immunity (2025)
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