Amor Vegas Lab
Principal Investigator: Corina Amor Vegas
Institution: Cold Spring Harbor Laboratory (Cold Spring Harbor, NY)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Hiring Postdocs
Research Focus
SUMMARY To date nine hallmarks of the aging process have been described, which can be grouped into three major categories: primary hallmarks or cause of damage (genomic instability, telomere attrition, epigenetic alterations and loss of proteostasis), antagonist hallmarks or responses to damage (cellular senescence, mitochondrial dysfunction and deregulated nutrient sensing) and integrative hallmarks or manifestations of the aging phenotype (stem cell exhaustion and altered intercellular communication). Despite intensive research on each individual hallmark, little is known about their interconnectivity and the hierarchies governing those interactions. A limiting factor in these studies is the time and resources needed for developing, breeding and aging mouse models that would allow to untangle the interactions as well as the lack of highly selective small molecules that would enable somatic approaches. In this regard, our recent work showed for the first time the feasibility of employing cellular therapy to eliminate cells that have entered a specific cellular program such as cellular senescence. In a proof- of-concept study we identified uPAR as a surface molecule upregulated in…
Active NIH Awards
- 5R01AG082800-04: Harnessing CAR T cells to deconstruct the interconnectivity among hallmarks of aging (2026)
- 4DP5OD033055-04: Deconstructing aging with senolytic CAR T cells (2025)
- 5R01AG082800-03: Harnessing CAR T cells to deconstruct the interconnectivity among hallmarks of aging (2025)
- 5DP5OD033055-03: Deconstructing aging with senolytic CAR T cells (2024)
- 5R01AG082800-02: Harnessing CAR T cells to deconstruct the interconnectivity among hallmarks of aging (2024)
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