Dos Santos Lab
Principal Investigator: Camila Dos Santos
Institution: St. Jude Children's Research Hospital (Memphis, TN)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Hiring Postdocs
Research Focus
CORE B – ORGANOID BIOBANK PROJECT SUMMARY Organoids are microscopic self-organizing, three-dimensional cellular structures that are grown from stem and progenitor cells in vitro. These culture models recapitulate many structural and functional aspects of their in vivo counterpart organs. This versatile technology has led to the development of many novel human cancer models, which have been widely validated as having superior capabilities to conventional 2D cancer cell lines in recapitulating human carcinoma biology. Over the last several years, several investigators at CSHL, including members of the Program, have come together to establish a unique Organoid Biobank. Through a productive collaboration with clinical oncologists, surgeons, and pathologists at several health centers, we have obtained hundreds of fresh tumor specimens, which have been adapted as primary cultures as organoids. Rigorous standard operating procedures annotated the genome and transcriptome of these cultures, resulting in the classification of each tumor organoid into molecular subtypes. Importantly, this biobank includes numerous basal-subtype models of pancreatic and breast carcinoma, which are a major foc…
Active NIH Awards
- 5P01CA013106-54: Core B: Organoid Biobank (2026)
- 7R01CA284630-04: Blockade of cMYC oncogenic function by pregnancy-induced alterations and remodeling of the mammary gland (2026)
- 5R01CA284630-03: Blockade of cMYC oncogenic function by pregnancy-induced alterations and remodeling of the mammary gland (2025)
- 5P01CA013106-53: Core B: Organoid Biobank (2025)
- 5R01AG069727-05: Defining the cellular and molecular effects of aging and age of pregnancy on breast tissue homeostasis and cancer initiation (2024)
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