Krainer Lab
Principal Investigator: Adrian R Krainer
Institution: Cold Spring Harbor Laboratory (Cold Spring Harbor, NY)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Accepting PhD Students ✅ Hiring Postdocs
Research Focus
OVERALL PROJECT SUMMARY The overall goal of this Program is to understand how transcription and splicing regulation is altered and co- opted by cancer cells to promote tumor initiation and progression, and to apply this knowledge towards development of new therapeutic approaches. During the past 50 years, the strong underlying basic science foundation of the Program Project has allowed members to identify vulnerabilities in cancer and develop novel and highly specific therapeutic strategies. This Program continues to take a multi-pronged approach grounded in basic cancer research to identify and disrupt the molecular dependencies underlying cancer. Within this Program, there are three highly integrated Projects (Targeting oncogenic transcription factors; RNA Splicing dysregulation in cancer; Regulatory RNAs as cancer drivers and dependencies) and four innovative Cores that are using cutting edge technologies to study the molecular mechanisms of cancer biology. To achieve the Program's goals, these studies will exploit novel organoid models of human cancers, pioneering imaging modalities in animal models, therapeutic antisense oligonucleotide strategies against otherwise undruggable…
Active NIH Awards
- 5P01CA013106-54: Targeting Transcription and Splicing in Cancer (2026)
- 5R01GM042699-35: Biochemistry of Pre-mRNA Splicing (2026)
- 5P01CA013106-54: Project 2: Splicing Dysregulation in Cancer (2026)
- 2P30CA045508-39: Antibody Technologies Shared Resource (2026)
- 2P30CA045508-39: Gene Regulation and Inheritance Program (2026)
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