Krasnitz Lab
Principal Investigator: Alexander Krasnitz
Institution: Cold Spring Harbor Laboratory (Cold Spring Harbor, NY)
Primary Subfield: Computational Biology
Recruitment Status: ✅ Hiring Postdocs
Research Focus
Project summary/abstract For multiple cancer types, epidemiological data exhibit strong correlations between, on the one hand, the incidence of the disease, its severity when diagnosed, and its clinical outcome, and, on the other hand, the ancestral background of the patient. This well-documented phenomenon strongly suggests a link between the biology and genetics of cancer in an individual and the individual's genetic ancestry. Indeed, recent research in cancer genomics, both pan-cancer and cancer type-specific, points to genetic and phenotypic differences between tumors occurring in patient populations with differing genetic ancestries, and to the need for more data collection to power further study in this area. It is the purpose of this proposal to facilitate such data analysis on a much greater scale, by enabling genetic ancestry inference directly from cancer-derived molecular data, without the need for the patient's cancer-free genotype or self-declared race or ethnicity. Successful completion of this project will unlock vast amounts of such data for ancestry- oriented studies of cancer from two major sources. One is the body of data stored by the Sequence Read Archive and s…
Active NIH Awards
- 5U01CA289357-03: Computational tools for accurate inference of genetic ancestry from cancer-derived molecular data (2026)
- 5U01CA289357-02: Computational tools for accurate inference of genetic ancestry from cancer-derived molecular data (2025)
- 1U01CA289357-01: Computational tools for accurate inference of genetic ancestry from cancer-derived molecular data (2024)
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