Mccandlish Lab
Principal Investigator: David Martin Mccandlish
Institution: Cold Spring Harbor Laboratory (Cold Spring Harbor, NY)
Primary Subfield: Computational Biology
Recruitment Status: ✅ Hiring Postdocs
Research Focus
Project Summary / Abstract How does the DNA sequence of an organism (genotype) determine its form and function (phenotype)? New technologies such as massively parallel reporter assays (MPRAs), deep mutational scanning, and combinatorial CRISPR screens have the potential to expose the genotype-phenotype relationship at an unprecedented level of detail by measuring phenotypes for tens of thousands to millions of genotypes in a single experiment. However, interpreting the results of these experiments is difficult because the space of genotypes is intrinsically high-dimensional and combinations of mutations often interact in complicated ways. My research program is focused on developing new computational tools to analyze data from these high-throughput experiments, with the goals of (1) identifying the major qualitative features of the genotype-phenotype relationship in specific biological systems, (2) explaining how these qualitative features arise from underlying developmental, cell biological and biophysical mechanisms, (3) being able to accurately predict the phenotypes of unmeasured genotypes, and (4) quantifying the uncertainty in these predictions. During the previous funding pe…
Active NIH Awards
- 5R35GM133613-07: Computational analysis of complex genetic interactions (2026)
- 2R35GM133613-06: Computational analysis of complex genetic interactions (2025)
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