Meyer Lab
Principal Investigator: Hannah Verena Meyer
Institution: Cold Spring Harbor Laboratory (Cold Spring Harbor, NY)
Primary Subfield: Immunology
Recruitment Status: ✅ Hiring Postdocs
Research Focus
PROJECT SUMMARY: Imbalance of immune and inflammatory activity is a hallmark of immune-mediated dis- eases. Genome-wide association studies have identified hundreds of loci that increase susceptibility to immune- mediated diseases. Functional effects of these genetic variants are difficult to infer as they might only impact a particular cell type and their effects may be restricted to specific points in development. Studies on adult immune cells have shed light on mediator cells and mechanisms of disease-associated variants, however, childhood is a critical yet understudied stage in the development of the immune system. Genetic determinants of T cell develop- ment and effector function during childhood have not been studied and their role in immune-mediated diseases is unknown. We propose to fill gaps that link the genetics of immune-mediated diseases to their effector cells, developmen- tal stages, and mechanisms. Our goals are 1) to understand the importance of genetically mediated T cell development and central tolerance induction on immune-mediated diseases and 2) to identify the importance of childhood immune phenotypes on disease in adulthood. To reach these goals, we propose stud…
Active NIH Awards
- 5R01AI167862-05: Dissecting dynamic genetic effects from thymus development to immune-mediated disease (2026)
- 5R01AI167862-04: Dissecting dynamic genetic effects from thymus development to immune-mediated disease (2025)
- 5R01AI167862-03: Dissecting dynamic genetic effects from thymus development to immune-mediated disease (2024)
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