Mcclure Lab
Principal Investigator: Allison Mcclure
Institution: University of Colorado Anschutz (Aurora, CO)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Accepting PhD Students ✅ Hiring Postdocs
Research Focus
SUMMARY Each cell cycle, the genome must be faithfully duplicated and then divided appropriately into two progeny cells. Most of the genome is replicated in S phase of the cell cycle, and the mechanisms of DNA replication are well-characterized. However, cells sometimes have not finished replicating the entire genome as they enter mitosis, the phase of the cell cycle when chromosomes are segregated eventually leading to cell division. Instead, these remaining regions are replicated in mitosis in a likely “last-ditch effort” to produce separable chromosomes: cells without it face aneuploidy or mitotic catastrophe. Despite the importance of mitotic DNA replication, the mechanisms governing it are poorly understood. To uncover the molecular mechanisms of mitotic DNA replication, our research program will use the biochemical reconstitution of DNA replication using purified budding yeast proteins, which is ideally suited for addressing direct mechanistic questions. We will complement this with yeast genetics approaches, known for their significant contributions to our understanding of the cell cycle and DNA replication. Additionally, we have developed innovative strategies that combine…
Active NIH Awards
- 5R35GM156773-02: Molecular mechanisms of DNA replication in mitosis (2026)
- 1R35GM156773-01: Molecular mechanisms of DNA replication in mitosis (2025)
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