Weinberg Lab
Principal Investigator: Adriana Weinberg
Institution: University of Colorado Anschutz (Aurora, CO)
Primary Subfield: Immunology
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Project Summary People with immunocompromising conditions, including end stage renal disease (ESRD) and renal transplantation, are at increased risk of developing severe infections. Vaccination is the preferred mode of protection against infections but people with the highest risk of infectious morbidity tend to have poor responses to vaccines. The recombinant zoster vaccine (RZV) showed excellent efficacy in healthy adults ≥50 years of age and lower immunogenicity and efficacy in transplant recipients. The goal of this study is to define the immunologic and metabolomic profiles associated with decreased magnitude and persistence of immune responses to RZV in people with ESRD before and after transplantation. We will use plasma and PBMC collected in a study of RZV in ESRD sponsored by GlaxoSmithKline, in which participants receive the standard 2-dose RZV immunization regimen while awaiting renal transplantation and are then followed for 31 months. Transplanted participants on stable immunosuppression are randomized to receive a 3rd dose of RZV or not and are followed for 12 additional months. Responses of these immunocompromised hosts are compared with responses of healthy adults ≥…
Active NIH Awards
- 5U01AI141919-08: PERSISTENCE OF IMMUNE RESPONSES TO THE RECOMBINANT ZOSTER VACCINE IN IMMUNE COMPROMISED HOSTS WITH END-STAGE RENAL DISEASE WITH AND WITHOUT KIDNEY TRANSPLANTATION (2026)
- 3R01HD116631-03S1: Developing Interventions for Protecting HIV-Exposed Uninfected Infants against Severe Infections (2026)
- 5R01HD116631-03: Developing Interventions for Protecting HIV-Exposed Uninfected Infants against Severe Infections (2026)
- 3R01HD116631-02S1: Developing Interventions for Protecting HIV-Exposed Uninfected Infants against Severe Infections (2025)
- 5U01AI141919-07: PERSISTENCE OF IMMUNE RESPONSES TO THE RECOMBINANT ZOSTER VACCINE IN IMMUNE COMPROMISED HOSTS WITH END-STAGE RENAL DISEASE WITH AND WITHOUT KIDNEY TRANSPLANTATION (2025)
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