Rebbeck Lab
Principal Investigator: Timothy Richard Rebbeck
Institution: Dana-Farber Cancer Institute (Boston, MA)
Primary Subfield: Genetics/Genomics
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
There is consistent evidence that germline genetics and tumor (somatic) genomics have a substantial impact on the incidence (occurrence) of prostate cancer. Prostate cancer incidence has one of the highest heritabilities of any common cancer. Over 450 low penetrance genetic variants have been identified by genome-wide association studies, and numerous high penetrance pathogenic variants are established to cause prostate cancer. In addition, there is growing evidence for substantial variation in the mutational landscape of prostate tumors. These pathways include known carcinogenesis mechanisms such as DNA damage repair, immunological surveillance, and steroid hormone metabolism. Molecularly-defined tumor subtypes are emerging that likely confer differences in prostate cancer progression and treatment response. These observations support the hypothesis that genetic and genomic factors influence prostate cancer incidence and tumor aggressiveness. Limited genetic variation to date has been available to inform the optimal clinical translation of genetic and genomic features for American men with prostate cancer. It has been demonstrated that research that does not account for the full r…
Active NIH Awards
- 5R01CA259200-05: Genomic and Genomic Variation in Prostate Cancer (2026)
- 3R01CA259200-05S1: Genomic and Genomic Variation in Prostate Cancer (2026)
- 3R01CA259200-05S3: Genetic and Genomic Variation in Prostate Cancer (2026)
- 3R01CA259200-05S2: Genetic and Genomic Variation in Prostate Cancer (2026)
- 3R01CA259200-05S7: Genetic and Genomic Variation in Prostate Cancer (2026)
Explore 700+ US Biology Labs on FindBioLabs.com