Zhao Lab
Principal Investigator: Jean Zhao
Institution: Dana-Farber Cancer Institute (Boston, MA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Accepting PhD Students ✅ Hiring Postdocs
Research Focus
Project Summary/Abstract Research in our laboratory is centered on understanding the diverse signaling networks regulating essential cellular processes in cancer, and how these affect the interplay between tumor, stromal and immune cells. Our research program combines a multi-pronged approach to advance basic scientific discoveries to pre-clinical, translational research and, ultimately, to clinical development. Our major goal is to develop safe and effective therapies for treating patients with cancer. Specifically, our research program will i) investigate the role of PI3K/PTEN signaling in shaping immune response in breast and prostate cancer, ii) investigate cellular and molecular mechanisms by which the immune system affects response to targeted therapies in breast cancer, and iii) investigate mechanisms of metastatic spread to the brain and treatment strategies against breast cancer brain metastasis (BCBM). To this end, we will capitalize on our expertise on signal transduction and pharmacology applied to genetically-engineered mouse models (GEMMs) and patient-derived xenografts (PDXs) to conduct multi-omics studies, as well as detailed mechanistic studies aimed to significant…
Active NIH Awards
- 5R35CA210057-11: Integrating targeted therapy and immunotherapy to break through cancer (2026)
- 5P01CA269021-03: Targeting replication stress to engage DNA sensing STING pathway derived anti-tumor immunity to improve the therapeutic outcomes in uterine cancer (2026)
- 5P01CA269021-02: Targeting replication stress to engage DNA sensing STING pathway derived anti-tumor immunity to improve the therapeutic outcomes in uterine cancer (2025)
- 5R35CA210057-10: Integrating targeted therapy and immunotherapy to break through cancer (2025)
- 5R35CA210057-09: Integrating targeted therapy and immunotherapy to break through cancer (2024)
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