Ackerman Lab
Principal Investigator: Margaret E Ackerman
Institution: Dartmouth College (Hanover, NH)
Primary Subfield: Immunology
Recruitment Status: ✅ Hiring Postdocs
Research Focus
ABSTRACT Antibody effector functions represent a nexus linking innate and adaptive arms of the immune system and also have direct clinical implications for antibody therapeutics and antibody-mediated pathologies. However, the potency of Ab-dependent effector responses depends on numerous antigen, antibody and effector cell properties. Variable antigen expression levels, accessibility and context on different targets influence not only Ab binding but also the ability of the effector cell to kill or engulf its target. Based on the extensive diversity of natural and engineered antibody forms and formats, both B cells and immunologists can engineer antibodies with different flexibility, affinity, and avidity to manipulate the effector response. The complexity of these interactions makes in vivo experimental testing of all combinations impractical, but the significance of these activities to antibody-based protection and pathology and the opportunity to design agents with a high probability of success once the fundamental cellular presentation mechanisms are understood makes quantitative analysis of this complex biological landscape of high significance. This proposal will elucidate our…
Active NIH Awards
- 5R01AI186995-02: Molecular characterization and modeling efficient antibody effector function (2026)
- 1R21AI195395-01: Targeting Evasion Factors: Discovery of novel antibodies for durable suppression of HSV reactivation (2026)
- 5R01AI183970-03: Mechanisms and means to improve HIV bnAb activity in vivo (2026)
- 5R01AI176646-04: Understanding and optimizing antibody-based interventions against neonatal HSV infection (2026)
- 5R01AI183970-02: Mechanisms and means to improve HIV bnAb activity in vivo (2025)
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