Dunlap Lab
Principal Investigator: Jay C. Dunlap
Institution: Dartmouth College (Hanover, NH)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Virtually all eukaryotic organisms appropriately examined have been shown to possess the capacity for endogenous temporal control and organization known as a circadian rhythm. The cellular machinery responsible for generating rhythms is collectively known as the biological clock. A healthy circadian clock underlies both physical and mental health. Because of the ubiquity of its influence on human mental and physiological processes - from circadian changes in basic human physiology to the clear involvement of rhythms in work/rest cycles and sleep - understanding the clock is basic to prevention and treatment of many physical and mental illnesses, from metabolic disorders to sleep/wake dysfunction and cancer. Our research uses genetic and molecular studies of the model eukaryote Neurospora, as well as mammalian cells in culture, to further our understanding of the organization of the circadian oscillator, a one- step transcription-translation feedback loop whose regulatory architecture is conserved from fungi to mammals. Planned research lies within three foci. Focus #1 builds upon our understanding of the interplay between structure and function in core clock components. We will det…
Active NIH Awards
- 5R35GM118021-10: Genetic and Molecular Dissection of the Neurospora Clock (2026)
- 5R35GM118021-09: Genetic and Molecular Dissection of the Neurospora Clock (2025)
- 5R35GM118021-08: Genetic and Molecular Dissection of the Neurospora Clock (2024)
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