Fang Lab
Principal Investigator: Hui Fang
Institution: Dartmouth College (Hanover, NH)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Abstract It has been highly challenging to scale up non-genetic, sub-second neuromodulator sensing or integrate it with electrical recording. Recently, we discovered that mild annealing dramatically improved the electrochemical stability of electroplated carbon coating and transformed conventional microelectrodes into sensors similar to carbon fiber electrodes with excellent neuromodulator-sensing performance based on fast-scan cyclic voltammetry (FSCV). Compared to previous carbonization strategies such as pyrolysis of polymer and laser- induced graphitization, low-temperature, FSCV-stable carbon coating is directly applicable to microelectrode arrays (MEAs), enabling unprecedented spatial scaling of FSCV and unparalleled integration with electrophysiological (ephys) recording, while leveraging decades of MEA research and applications. As a demonstration, we have created a monolithic MEA probe with integrated ephys and FSCV capabilities and validated it in vivo in multiple rodent models. Early studies using this probe in awake rats further revealed an unprecedented correlation between striatal gamma oscillation and dopamine release. In three parallel aims, we intend to optimize, b…
Active NIH Awards
- 5R01MH139342-02: Multimodal MEAs for Parallel Electrical Recording and Sub-second Neuromodulator Sensing (2026)
- 1R18NS145979-01: Translating Novel Carbon Coating Towards Integrated Sub-second Neurotransmitter Sensors in Humans (2026)
- 1R01MH139342-01: Multimodal MEAs for Parallel Electrical Recording and Sub-second Neuromodulator Sensing (2025)
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