Micalizio Lab
Principal Investigator: Glenn C Micalizio
Institution: University of California, Irvine (Irvine, CA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Accepting PhD Students
Research Focus
1. Project Summary/Abstract: Research Overview – Research is focused on organic synthesis, with particular interest in developing synthesis strategies and modes of reactivity within organic chemistry that facilitate the construction of complex molecules with potentially valuable medicinal and/or biological properties. We have developed over thirty stereoselective C–C bond-forming reactions based on areas of reactivity that include metallacycle-mediated cross-coupling, [3+2] cycloaddition, vinylcyclopropane rearrangement, and radical cascade chemistry. While some of these have been developed within a program aimed at achieving a foundation of reactivity suitable to realize a wide range of unique “convergent” C–C bond forming processes, others have emerged within programs in the broad area of natural product synthesis. These combined activities, that aim to advance the fundamental backbone of organic chemistry through innovation within the field of stereoselective synthesis, are routinely embraced as enabling technology to fuel exploration in medicinally relevant science. For example, we have discovered: (1) a non-opioid analgesic from efforts targeting the alkaloid conolidine, (2) u…
Active NIH Awards
- 1R35GM163463-01: Natural Product-Inspired Advances in Stereoselective Synthesis (2026)
- 5R35GM134725-05: Metallacycle-mediated coupling in stereoselective synthesis (2024)
- 7R35GM134725-06: Metallacycle-mediated coupling in stereoselective synthesis (2024)
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