Pogue Lab
Principal Investigator: Brian William Pogue
Institution: Dartmouth College (Hanover, NH)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
ABSTRACT Significant improvement in the effectiveness of radiation therapy (RT) now seems possible because of recent exciting research results using ultra-high dose rates (UHDR), indicating that normal tissue damage can be reduced (the `FLASH' effect), compared to conventional radiation for the same total dose. FLASH RT delivery has shown reduced morphological and functional damage to normal tissues such as brain, colon, lung, and skin. Although significant research remains, early indications are that the normal tissue sparing effect may as high 50% at some dose levels. If proven in translation, this effect would be the most significant improvement in RT therapeutic ratio since the advent of treatment planning. While intriguing mechanisms for this result have been postulated, they remain only well-reasoned speculations because of a lack of direct in vivo data on the physico- chemical mechanisms including oxygen depletion and free radical species alterations. Dartmouth has created the first reversible MeV FLASH beam on a clinically commissioned linac with >100 Gy/s at the patient treatment bed, and prototyped an open-source treatment planning system, expanding research access. Addit…
Active NIH Awards
- 5U01CA260446-05: Optimization of MeV FLASH radiotherapy for normal tissue preservation (2026)
- 5R01EB033877-04: Cherenkov Excited Luminescence Metabolic Sensing (CELMS) (2026)
- 5R01CA271330-04: Oxygen Dynamics in FLASH Radiotherapy (2026)
- 5U01CA260446-04: Optimization of MeV FLASH radiotherapy for normal tissue preservation (2025)
- 7R01CA271330-03: Oxygen Dynamics in FLASH Radiotherapy (2025)
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