Zhao Lab
Principal Investigator: Siming Zhao
Institution: Dartmouth College (Hanover, NH)
Primary Subfield: Genetics/Genomics
Recruitment Status: ✅ Hiring Postdocs
Research Focus
Project Summary Common genetic variation is an important player in human diseases. One central goal of human genetic studies is to identify causal genetic variants in diseases and understand the mechanism. Many genome-wide association studies (GWAS) have been performed to identify associations between genetic variants and a myriad of human diseases. However, moving from GWAS results to identification of causal variants, and a mechanistic understanding of how the variants elicit diseases remains a major challenge in the field. This challenge is what I aim to address in my research program. Recent research efforts have led to the generation of large scale functional genomic datasets, in particular single cell transcriptomic and epigenomic data. Because most common variants are located in noncoding genomic regions and their functional effects are mostly unknown, such functional genomic datasets have the potential to provide important information about the variant’s functional role, for example if a variant has gene regulatory effect, which cell or tissue type it has an effect in, if such an effect is related to diseases, etc. However, the current methods and analyses used by researche…
Active NIH Awards
- 5R35GM154925-03: Statistical methods and analyses to study genetic variants and their roles in diseases leveraging functional genomics data. (2026)
- 5R35GM154925-02: Statistical methods and analyses to study genetic variants and their roles in diseases leveraging functional genomics data. (2025)
- 1R35GM154925-01: Statistical methods and analyses to study genetic variants and their roles in diseases leveraging functional genomics data. (2024)
- 2P20GM130454-06: Zhao - Proj 2 (2024)
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