Birey Lab
Principal Investigator: Fikri Birey
Institution: Emory University (Atlanta, GA)
Primary Subfield: Neuroscience
Recruitment Status: ✅ Hiring Postdocs
Research Focus
ABSTRACT Assembly of the brain relies upon spatiotemporally coordinated action of a small number of intracellular signaling pathways, which together govern an astonishingly wide array of processes, ranging from cell differentiation to tissue morphogenesis. How a handful of pathways can provide the precision and specificity required for the emergence of complex tissue structure and function that unfold over long periods of time, such as those of the human brain, has been a long-standing question in developmental biology. Even though landmark studies in developmental genetics, biochemistry and synthetic biology over the last decades have uncovered the working mechanisms of many signaling pathways and downstream genetic circuits, a major challenge that remains is to decipher how cells integrate information transmitted through the concerted action of several signaling factors which then drive region-specific morphogenetic processes in developmentally relevant contexts. Moreover, although the key components of these pathways are highly conserved across species, how they are functionally implemented to enable uniquely complex stratification of regions and cell types during brain developm…
Active NIH Awards
- 5R01MH133612-03: Elucidating the Signaling Landscapes Underlying Cellular and Regional Specification During Human Brain Development (2026)
- 1R21MH144466-01: Multiplexed Functional Mapping of CACNA1C Disease Variants in hiPSC-Derived Neurons (2026)
- 5R01MH133612-02: Elucidating the Signaling Landscapes Underlying Cellular and Regional Specification During Human Brain Development (2025)
- 5R00MH119319-05: Investigating the role of TCF4 in human interneuron function and dysfunction (2024)
- 1R01MH133612-01A1: Elucidating the Signaling Landscapes Underlying Cellular and Regional Specification During Human Brain Development (2024)
Explore 700+ US Biology Labs on FindBioLabs.com