Lowen Lab
Principal Investigator: Anice C Lowen
Institution: Emory University (Atlanta, GA)
Primary Subfield: Immunology
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
SUMMARY Influenza A viruses (FLUAVs) circulate in a wide range of avian and mammalian hosts. Specific viral lineages are host restricted and tend to transmit among individuals of one or a small number of related species. Host range expansion is relatively common, however, with spillover between species occasionally giving rise to novel lineages and – with them – novel outbreaks. Owing to their implications for human and animal health, the drivers of and barriers to viral host range expansion garner significant attention. Much of this attention focuses at molecular and cellular levels, however, leaving a gap in understanding the impact of host differences on virus- host interactions that play out within tissues, between tissues and between individuals. These interactions are complex and multi-faceted. They are also highly consequential: they shape viral populations, define disease outcomes, and determine the potential for onward transmission. Thus, host specific differences in viral population structure and dynamics represent a major uncharted area of virology. To address this gap, we will examine FLUAV dynamics in a diverse set of host species, including multiple natural hosts, dep…
Active NIH Awards
- 5R01AI127799-07: Host dependence of influenza A virus spatio-temporal dynamics (2026)
- 5P01AI186819-02: Drivers of influenza A virus transmission in humans (2026)
- 1R01AI201564-01: Reassortment of Highly Pathogenic Avian Influenza: Implications for Fitness and Host Range (2026)
- 5P01AI186819-02: Administrative Core - Drivers of influenza A virus transmission in humans (2026)
- 5R01AI165644-05: Impact of intra-host population structure on influenza virus antigenic evolution (2026)
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