Hsu Lab
Principal Investigator: Li Hsu
Institution: Fred Hutch Cancer Center (Seattle, WA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY/ABSTRACT Prevention holds the greatest potential for reducing cancer burden in the population. Recent breakthroughs in genomics technologies have propelled advancements in deciphering molecular events and understanding cancer causes, leading to improved risk stratification and precision prevention. The objective of this application is to develop statistical and computational approaches to harness state-of-the-art genomic data and translate these findings into precision prevention through risk-based intervention strategies. Tumors are heterogeneous and unraveling tumor heterogeneity to distinguish indolent versus aggressive tumors will facilitate the understanding of underlying disease process. Emerging spatial omics technology, which simultaneously profiles both molecular features and spatial locations, provides critical information about the tissue microenvironment essential for understanding disease development. There are significant challenges in analyzing such data, including non-comparability of spatial omics images from different samples, high-dimensional data, and limited sample size. The goal of Aim 1 is to develop (a) deep learning-based approaches that com…
Active NIH Awards
- 5R01CA297681-02: Statistical Methods for Precision Prevention (2026)
- 5P50CA285275-03: Core C: Biostatistics and Bioinformatics Core (2026)
- 1R01CA297681-01: Statistical Methods for Precision Prevention (2025)
- 5P50CA285275-02: Core C: Biostatistics and Bioinformatics Core (2025)
- 5R01HL152439-04: Integrative Genomics into Genetic Association Studies of Blood Pressure and Stroke in African Americans (2024)
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