Parkhurst Lab
Principal Investigator: Susan M Parkhurst
Institution: Fred Hutch Cancer Center (Seattle, WA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Hiring Postdocs
Research Focus
PROJECT SUMMARY/ABSTRACT Dynamic interactions between intercellular membranes and the cortical cytoskeleton are critical for cell survival. During their normal functions, cells face physiological and environmental stresses that can lead to rupture of the plasma membrane and/or of the nuclear envelope. Rapid repair of such injuries, whether arising from daily activities or resulting from trauma, infection, or diseases such as cancer, is an active area of cell biology research. My lab has a long-standing track record in successfully identifying key molecules and elucidating their in vivo roles at the cell cortex necessary for the repair of plasma membrane and at the nuclear envelope necessary for repair of the nuclear cortex. The overall focus of the lab is to delineate how cells deal with such cell and/or nuclear cortex disruptions to efficiently and effectively repair the lesions. We have developed a robust inducible single cell repair model using the syncytial Drosophila embryo that has superb amenability for live imaging and genetic tractability that is unavailable in other cell wound repair models. We have also established a model for the newly appreciated nuclear export pathway…
Active NIH Awards
- 1R35GM161275-01: Mechanisms of Dynamic Cytoskeleton and Membrane Interactions (2026)
- 5R01GM111635-12: Molecular and Cellular Mechanisms of Wound Repair (2025)
- 5R01GM143186-05: Cellular mechanisms of nucleocytoplasmic export through Nuclear Envelope Budding (2024)
- 5R01GM111635-11: Molecular and Cellular Mechanisms of Wound Repair (2024)
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