Setty Lab
Principal Investigator: Manu N Setty
Institution: Fred Hutch Cancer Center (Seattle, WA)
Primary Subfield: Computational Biology
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Project Summary Cellular differentiation is a fundamental biological process through which complex multi-cellular organisms develop from single-cell embryos and maintain tissue homeostasis throughout life. Cells integrate signals from the microenvironment and transmit them to downstream transcriptional regulators, which execute the expression and chromatin changes to define phenotypic state transitions in differentiation trajectories. Elucidating the principles of how cells choose their fate, and the path they take to get there, is a major challenge in the field. Single-cell (sc) RNA sequencing technologies are revolutionizing our understanding of the cellular spatio- temporal trajectories that shape differentiation. The emergence of additional high throughput, multimodal technologies such as paired RNA&ATAC-seq, scCUT&Tag and spatial technologies provide unprecedented opportunities to extract mechanistic insights into the lineage decisions that underly differentiation trajectories. This proposal aims to exploit this enormous potential by developing sophisticated new algorithms that integrate single-cell measurements to model and interpret complex biology. Through analysis of multi…
Active NIH Awards
- 5R35GM147125-05: Computational Modeling of Lineage Decisions using Single-cell Data (2026)
- 5R35GM147125-04: Computational Modeling of Lineage Decisions using Single-cell Data (2025)
- 5R35GM147125-03: Computational Modeling of Lineage Decisions using Single-cell Data (2024)
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