Liu Lab
Principal Investigator: Jia Liu
Institution: Harvard University (Cambridge, MA)
Primary Subfield: Computational Biology
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
The ability to control and monitor the maturation of human-induced pluripotent stem cell (hiPSC)-derived tissues is critical for tissue engineering, regenerative medicine, pharmacology, and synthetic biology. This proposal presents an artificial intelligence (Al)-driven "cyborg tissue" platform that integrates tissue-like flexible electronic sensors and actuators with developing tissues and provides multimodal recording and control. Machine learning-based mathematical models will be built to integrate the data and tissue maturation status readout through the in situ single-cell RNA sequencing. This closed-loop system will control the tissue-wide distributed electrical actuations to promote tissue development. The aim is to use hiPSC-derived cardiac organoids as a model system to demonstrate that this Al-driven cyborg tissue platform can improve the maturation and eliminate the variations in patient-specific hiPSC-derived tissue samples. Specifically, flexible and stretchable mesh nanoelectronics with miniaturized multifunctional sensors and electrical stimulators will be fully implanted, integrated, and distributed across the entire three-dimensional (3D) volume of organoids for co…
Active NIH Awards
- 5R01LM014465-04: SCH: Al-driven Flexible Electronics for Cardiac Organoid Maturation (2026)
- 5R01NS137082-02: Type 2 diabetes induced chronic inflammation on stroke outcome (2026)
- 1R21AG087044-01A1: In vivo testing of structure-based vaccine candidates targeting Alzheimer’s disease (2025)
- 5R01LM014465-03: SCH: Al-driven Flexible Electronics for Cardiac Organoid Maturation (2025)
- 1R01NS137082-01A1: Type 2 diabetes induced chronic inflammation on stroke outcome (2025)
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