Vidal Lab
Principal Investigator: Ruben Vidal
Institution: Indiana University Indianapolis (Indianapolis, IN)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Project Summary/Abstract Recently, significant progress in understanding tauopathies and how tau aggregates lead to neurodegeneration has been made by the description of the atomic structures of tau filaments from human brain. We have established that the morphology of tau filaments comprising of all six tau isoforms (3R+4R tau) in diseases associated with extracellular amyloid deposition is identical, regardless of the amino acid sequence of the amyloid subunit. To gain further understanding on how different amyloids elicit a tau response comprising of 3R+4R tau with a common fold (AD fold), we characterized the structures of filaments of human extracellular amyloid-β (Aβ) in Alzheimer disease (AD) and Prion protein amyloid (APrP) in Prion diseases. In addition, we characterized the structures of α-synuclein filaments in Diffuse Lewy body disease, Parkinson disease and Multiple system atrophy, and TMEM106B filaments in several neurodegenerative diseases and aging. The studies proposed in this MPI application are a logical continuation of this groundbreaking work. These studies are in response to PAR-22-208 “Structural Biology of Alzheimer's Disease Related Dementias (ADRDs) Protei…
Active NIH Awards
- 3R01NS110437-07S1: Structure of amyloid fibrils in human neurodegenerative diseases and aging (2026)
- 4R01NS110437-07: Structure of amyloid fibrils in human neurodegenerative diseases and aging (2026)
- 5R01AG080001-04: Identification of novel four repeat tauopathies through analysis of network vulnerability, tau structure and propagation. (2026)
- 5R01AG071177-03: Structural analysis of tau associated with parenchymal and vascular prion protein amyloidosis (2025)
- 5R01AG080001-03: Identification of novel four repeat tauopathies through analysis of network vulnerability, tau structure and propagation. (2025)
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