Li Lab
Principal Investigator: Ming Li
Institution: Indiana University (Bloomington, IN)
Primary Subfield: Genetics/Genomics
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Project Summary Congenital heart defects (CHDs) are the most prevalent type of birth defects and the leading cause of infant mortality attributable to birth defects. Most CHDs are thought to result from a complex interaction between maternal exposures and genetic susceptibilities. In the past decade, large-scale genome-wide association studies and whole-genome sequencing studies have been conducted to comprehensively investigate the role of a deep catalog of genetic variants in CHDs. Although substantial progress has been made in the identification of individual genetic variants associated with CHDs, the complex interactions during embryogenesis have not been well understood. There has been even less success to identify rare genetic variants with heterogenous effect and the regulatory pathways among genetic variants, epigenetic modifications, and transcriptional changes leading to the disease development. To date, the etiology of CHDs has remained largely unknown, and the disease risk prediction models generally have low clinical utility. The proposed research aims to address the heterogeneous, interactive, and multi-omic etiology of CHDs by leveraging existing resources from multi…
Active NIH Awards
- 1R01HL171194-01A1: Random field methods for integrative genomic analysis and high-dimensional risk prediction of congenital heart defects (2026)
- 3R01HL171194-01A1S1: Random field methods for integrative genomic analysis and high-dimensional risk prediction of congenital heart defects (2026)
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