Lin Lab
Principal Investigator: Dingchang Lin
Institution: Johns Hopkins University (Baltimore, MD)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Project Summary The brain is nature’s most sophisticated signal-processing system. Unlike human-made integrated circuits, the brain circuits organize in a complex three-dimensional and intertwined manner, which makes it challenging to spatially resolve neuronal activities. Among all available neural recording technologies, penetrating neural probes hold great promise and are vital to neuroscience research. In common practice, neural probes are linearly inserted into the brain to map the local activity, which, however, can only probe a single spot in the targeted brain region. An entire circuit or structure can be mapped by deploying multiple probes, but the spatial resolution is modest. To date, how to spatially resolve single-unit activities from nonlinearly organized brain structures and circuits is still a challenge. Here, we propose to fill the technological gap via a nonlinear probe implantation modality. In contrast to the conventional linear implantation, we will conformally deploy high-density microelectrode arrays along designated curved brain circuits or structures with minimal surgical lesions. Ultraflexible neural probes with high electrode density will be designed acco…
Active NIH Awards
- 5R21EY035955-03: Curved Implantation of Flexible Microelectrode Arrays for High-Density Mapping of Nonlinear Brain Structures and Circuits (2026)
- 5R35GM147274-05: Protein assemblies as genetically encoded mechanical actuators for intracellular mechanobiology research (2026)
- 5R21EY035955-02: Curved Implantation of Flexible Microelectrode Arrays for High-Density Mapping of Nonlinear Brain Structures and Circuits (2025)
- 5R35GM147274-04: Protein assemblies as genetically encoded mechanical actuators for intracellular mechanobiology research (2025)
- 1R21EY035955-01: Curved Implantation of Flexible Microelectrode Arrays for High-Density Mapping of Nonlinear Brain Structures and Circuits (2024)
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