Regot Lab
Principal Investigator: Sergi Regot
Institution: Johns Hopkins University (Baltimore, MD)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: ✅ Accepting PhD Students ✅ Hiring Postdocs
Research Focus
Project Summary Cells have a remarkable ability to reproducibly respond to a changing environment even with promiscuous protein-protein interactions, stochastic gene expression, and macromolecular crowding. Our goal is to identify and characterize the mechanisms that robustly amplify signaling events over noise to govern cell biology and ultimately coordinate collective cell behavior. We use as a model the Mitogen Activated Protein Kinase (MAPK) pathway, a conserved signaling network involved in virtually all aspects of cell biology. Our focus on quantitatively understanding the timing of signaling events at the single cell and single molecule levels in the context of physiologically relevant multicellular systems allows us to dissect how signal and noise relate to functional outcome. We have developed biosensors and fully automated imaging platforms to simultaneously quantify multiple kinase activities in thousands of live single cells. More recently, we have generated transgenic mouse models to monitor signaling events in unperturbed mouse tissues and developing embryos. Using these approaches we have uncovered spatial and temporal patterns of signaling events that filter biologi…
Active NIH Awards
- 5R35GM133499-07: Single Cell Analysis of MAPK Signaling Dynamics in Multicellularity (2026)
- 5R01CA266199-05: The role of TRIM37 in driving tumorigenesis and cancer-specific vulnerability to PLK4 inhibition (2026)
- 5R01CA279546-03: Causes and Consequences of Whole Genome Duplication in Cancer Progression and Acquired Drug Resistance (2026)
- 2R35GM133499-06: Single Cell Analysis of MAPK Signaling Dynamics in Multicellularity (2025)
- 5R01CA279546-02: Causes and Consequences of Whole Genome Duplication in Cancer Progression and Acquired Drug Resistance (2025)
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