Trapecar Lab
Principal Investigator: Martin Trapecar
Institution: Johns Hopkins University (Baltimore, MD)
Primary Subfield: Immunology
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY Total transplantation of the immune system via bone marrow transplantation is a critical treatment for various conditions, yet it faces significant challenges, most notably Graft versus Host Disease (GVHD). This project proposes a transformative approach to understand and mitigate GVHD, especially in pediatric patients. We aim to develop a groundbreaking multi-tissue Organotypic Culture Model (OCM) that integrates gut, liver, and blood components to replicate the complex immune interactions occurring during acute GVHD with intestinal and hepatic involvement. This model will provide a physiologically relevant platform to study donor-recipient immune responses in bone marrow transplantation, overcoming the limitations of current in vitro models. Central to our approach is the creation of patient-specific OCMs using tissues from pediatric bone marrow transplant recipients. This personalized methodology allows for an in-depth understanding of individual GVHD responses and the potential for tailored therapeutic strategies, thus advancing precision medicine in transplant immunology. Specifically, we will first develop a gut-liver-immune OCM platform to study the impact of…
Active NIH Awards
- 1R01AI201543-01: Engineering patient avatars of hematopoietic stem cell transplantation to study GvHD (2026)
- 5R35GM146900-05: Uncovering the hidden universe of metabolite-specific T lymphocytes,using human multiorgan microphysiological systems. (2026)
- 5R35GM146900-04: Uncovering the hidden universe of metabolite-specific T lymphocytes,using human multiorgan microphysiological systems. (2025)
- 5R35GM146900-03: Uncovering the hidden universe of metabolite-specific T lymphocytes,using human multiorgan microphysiological systems. (2024)
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