Undem Lab
Principal Investigator: Bradley Joel Undem
Institution: Johns Hopkins University (Baltimore, MD)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Project Summary/ Abstract Basic and clinical research over the past decade is shedding new light on the major role played by the nervous system in respiratory pathophysiology, in particular in the “hypertussivity” associated with chronic unproductive cough, in the “airways hyperresponsiveness”” associated with of asthma, and in the airway narrowing and secretions associated with COPD. The evidence supports the hypothesis that these hyperactive disorders are in part secondary to dysregulation of vagal afferent C-fibers that comprise some 75% of the nerves within the respiratory tract. This grant aims to advance our understanding of the nature of the inflammatory mediators (autacoids and cytokines) responsible for activating airway C-fibers and the specific ionic mechanisms underlying this activity. This R35 will replace my two active R01 grants: R01 HL137807 “Mechanisms of Inflammatory Activation of Vagal C-Fibers in the Respiratory Tract” and R01HL122228 “Control of Airway Sensory Nerve Function by Voltage- Gated Sodium Channel Subtypes.” The R35 funding will allow us to go beyond the aims of the R01 grants that focus on healthy animals, and delve into the mechanisms that lead to t…
Active NIH Awards
- 5R35HL155671-06: Neurobiology of the Bronchopulmonary System (2026)
- 5R35HL155671-05: Neurobiology of the Bronchopulmonary System (2025)
- 5R35HL155671-04: Neurobiology of the Bronchopulmonary System (2024)
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