Zandi Lab
Principal Investigator: Peter P. Zandi
Institution: Johns Hopkins University (Baltimore, MD)
Primary Subfield: Neuroscience
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Bipolar disorder (BP) is a severe multifactorial neuropsychiatric disorder that imposes a significant burden on public health. The most recent large-scale genetic study of BP identified 64 associated genetic loci, providing initial insights in BP pathogenesis. Yet, genetic discovery in BP lags behind other key psychiatric disorders. The reported genetic loci only captures a small proportion of the total BP genetic liability, with many more variants across the common and rare allele frequency spectrum remaining to be discovered. In addition, the previous studied samples were of European ancestry, leaving population specific BP variants uncovered and uncertainty in how the BP genetic findings generalize to other populations, and these studies rarely employed “deep” phenotyping or assessed relevant environmental risk factors. This proposal brings together an international collaboration of leading investigators from the U.S. and Asia to form the Asian Bipolar Genetics Network (A-BIG-NET) and carry out a large-scale genetic study of BP in East and South Asia. A-BIG-NET will generate a BP genetic resource of 27,500 cases and 16,000 controls with rich phenotypic information, measures of k…
Active NIH Awards
- 5R01MH130673-05: 3/4 Asian Bipolar Genetics Network (A-BIG-NET) (2026)
- 5R01MH121542-05: 1/2 Genetics at an extreme: an efficient genomic study of individuals with clinically severe major depression receiving ECT (2025)
- 5R01MH130673-04: 3/4 Asian Bipolar Genetics Network (A-BIG-NET) (2025)
- 5R01MH130673-03: 3/4 Asian Bipolar Genetics Network (A-BIG-NET) (2024)
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