Bathe Lab
Principal Investigator: Mark Bathe
Institution: Massachusetts Institute of Technology (Cambridge, MA)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
PROJECT SUMMARY Over 7 million Americans suffer from Alzheimer’s Disease (AD), presenting a major health burden to patients and their caregivers, and claiming over a hundred thousand lives annually. AD remains without any effective cure or treatments, despite decades of research into small molecule- and antibody-based therapeutics. In contrast, next-generation therapeutic nucleic acids (TNAs) such as short interfering RNAs (siRNAs), anti-sense oligonucleotides (ASOs), and messenger RNAs (mRNAs) have major potential to treat AD due to their ability to modulate the expression of nearly any gene in any cell-type, if only they can be delivered safely and effectively to target brain cells that reside across the blood-brain barrier. Non-viral vectors are a promising new class of delivery vectors that could in principle transport TNAs to specific regions and cell types of the brain for potent, durable gene modulation to revolutionize clinical treatment of AD and other neurodegenerative and neurological disorders and diseases. The intrathecal administration route has emerged as a leading technique for delivering TNAs as it bypasses the intractable problems associated with blood-brain barri…
Active NIH Awards
- 1R21AG099044-01: Pilot of a new non-viral vector for therapeutic nucleic acid delivery to the CNS (2026)
- 2R01AI162307-05: Investigation of Synthetic DNA-based Viral Particles for Spatially Controlled Antigen Presentation (2026)
- 5R01MH112694-07: Simultaneous profiling of neuronal synapse activities, proteins, and messenger RNAs at the single-cell level (2026)
- 2R01MH112694-06: Simultaneous profiling of neuronal synapse activities, proteins, and messenger RNAs at the single-cell level (2025)
- 5R01AI162307-04: Investigation of Synthetic DNA-based Viral Particles for Spatially Controlled Antigen Presentation (2024)
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