Keating Lab
Principal Investigator: Amy E Keating
Institution: Massachusetts Institute of Technology (Cambridge, MA)
Primary Subfield: Computational Biology
Recruitment Status: ✅ Accepting PhD Students ✅ Hiring Postdocs
Research Focus
Protein-protein interactions transmit information, shape cell structure, assemble complexes, and enable chemical transformations that support life. Mapping and decoding the human interactome to establish which interactions occur, what functions they support, and how interactions are altered in disease are critical goals for biology. There is also a biomedical imperative to learn to inhibit or modulate protein interactions for discovery research and the development of new therapies. This proposal presents an integrated program of computational and experimental studies of protein-protein interactions that involve short linear motifs (SLiMs) binding to modular, structurally conserved interaction domains. SLiM are abundant, with estimates of more than 105 binding motifs in the human proteome, and they play critical roles in signal transduction and the assembly of structural and regulatory complexes that are implicated in disease. The domains that bind to SLiMs, such as EVH1, TRAF, SH3, WW, etc., occur in many copies in the proteome due to the expansion of paralogous families by domain duplication and divergence. This research program will address two key questions. (1) The paralog spec…
Active NIH Awards
- 5R35GM149227-04: Computational and Experimental Investigation and Design of Protein Interaction Specificity (2026)
- 5R35GM149227-03: Computational and Experimental Investigation and Design of Protein Interaction Specificity (2025)
- 5R35GM149227-02: Computational and Experimental Investigation and Design of Protein Interaction Specificity (2024)
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