Kellis Lab
Principal Investigator: Manolis Kellis
Institution: Massachusetts Institute of Technology (Cambridge, MA)
Primary Subfield: Neuroscience
Recruitment Status: ✅ Accepting PhD Students ✅ Hiring Postdocs
Research Focus
Abstract HIV-associated neurocognitive disorders (HAND), substance use disorders (SUD), Alzheimer's Disease (AD), and neuropsychiatric conditions share converging mechanisms of neuroinflammation, immune dysregulation, synaptic dysfunction, and neuronal injury that accelerate cognitive decline. Moreover, SUD and neuropsychiatric disorders co-occur at higher frequencies in persons living with HIV (PLWH) than in the non-HIV population, making it difficult to untangle the influence of these shared genetic mechanisms on progression of the diseases. The Single Cell Opioid Responses in the Context of HIV (SCORCH) consortium aims to address this complex interplay between HIV, substance use disorders (SUDs), and neuropsychiatric conditions. Leveraging the extensive data from SCORCH, PsychENCODE, and Alzheimer’s Disease (AD) datasets, our proposal aims to uncover the genetic and molecular mechanisms driving the interactions between HIV, neuropsychiatric, and neurodegenerative conditions. We employ advanced computational techniques to identify differences in gene expression across disorders, with a focus on identifying shared and distinct drivers of HIV and SUD impact on psychiatric genes and…
Active NIH Awards
- 5R01DA063327-02: Integration and Validation of Single-Cell Neuronal and Immune Molecular Responses in SUD and HIV (2026)
- 5R01NS129032-03: Single-cell multi-region transcriptional and epigenomic dissection of VCID. (2026)
- 5R01AG081017-04: Single-cell multi-region dissection of AD-pathogen interactions for HSV-1 and CMV (2026)
- 5U01DA053631-05: Single Cell Transcriptomic and Epigenomic Dissection of Opioid and Cocaine Responses in HIV (2025)
- 5R01AG067151-05: Single-Cell Transcriptional and Epigenomic Dissection to Identify Therapeutic Targets for ALS and FTD (2025)
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