Hanash Lab
Principal Investigator: Alan M Hanash
Institution: Memorial Sloan Kettering Cancer Center (New York, NY)
Primary Subfield: Molecular & Cell Bio
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
Intestinal injury is a major complication of allogeneic hematopoietic transplantation, limiting its wider use. The immune system plays a pivotal role in causing intestinal pathology in graft vs. host disease (GVHD) occurring post-transplant, but the immune system can also provide critical contributions to epithelial regeneration and in- testinal repair. We have found that immune-mediated interactions with the intestinal stem cell (ISC) compartment are important contributors to both the damage and regeneration occurring in the intestines in acute GVHD, and the previous funding period resulted in several impactful contributions to understanding immunologic effects on the ISC compartment after bone marrow transplantation (BMT), including that 1) the crypt base ISC compartment is the initial site of donor T cell infiltration within the intestines, where their overproduction of Interferon-g (IFNg) can directly induce Bax/Bak-dependent ISC apoptosis at high concentrations; and 2) Interleukin-(IL-)22 can di- rectly signal to ISCs, promoting their survival and regeneration after damage, and it can be administered thera- peutically post-BMT to promote thymic and intestinal recovery. IL-22 a…
Active NIH Awards
- 5R01HL125571-07: Regulation of the intestinal stem cell compartment after hematopoietic transplantation (2026)
- 5R01HL146338-07: Discriminating EGFR function in T cells and epithelium during immune-mediated tissue damage (2026)
- 2R01HL125571-06: Regulation of the intestinal stem cell compartment after hematopoietic transplantation (2025)
- 5R01HL146338-06: Discriminating EGFR function in T cells and epithelium during immune-mediated tissue damage (2025)
- 5R01HL145631-04: T cell invasion of the stem cell compartment during immune-mediated GI damage (2024)
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