Leslie Lab
Principal Investigator: Christina S Leslie
Institution: Memorial Sloan Kettering Cancer Center (New York, NY)
Primary Subfield: Genetics/Genomics
Recruitment Status: Inquire for rotation/fellowship opportunities
Research Focus
NO CHANGE FROM ORIGINAL SUBMISSION Abstract Natural genetic variation impacts most human diseases, yet predicting how regulatory variants control gene expression and ultimately disease phenotypes poses considerable challenges. First, the polygenic inheritance influencing most conditions requires consideration of a vast number of genes and regulatory elements. This task is challenged by the complexity of gene regulation, where 3D regulatory interactions can link enhancers and genes over large genomic distances. Second, multiple interacting cell types are often dysregulated in disease pathology. This necessitates an understanding of how the collective variants associating with a disease affect each cell type involved in the disease process and subsequently how these dysregulated cellular phenotypes crossregulate and drive subsequent cellular states. In this IGVF project, we will use rheumatoid arthritis (RA), a human autoimmune inflammatory disease, as a case study to develop robust machine learning models of gene regulation to decipher the impact of genomic variation on multiple cellular drivers of pathology—namely, inflammatory T cell and fibroblast subsets found in affected joint…
Active NIH Awards
- 3U01HG012103-05S1: Deciphering the genomics of gene network regulation of T cell and fibroblast states in autoimmune inflammation (2026)
- 5U54CA274492-05: Administrative Core (2026)
- 5U54CA274492-05: The Center for Tumor-Immune Systems Biology at MSKCC (2026)
- 5U54CA274492-04: Administrative Core (2025)
- 5U01HG012103-05: Deciphering the Genomics of Gene Network Regulation of T Cell and Fibroblast States in Autoimmune Inflammation (2025)
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